Comment on "A common genetic variant is associated with adult and childhood obesity".
نویسندگان
چکیده
Herbert et al. (Reports, 14 April 2006, p. 279) reported an association between the INSIG2 gene variant rs7566605 and obesity in four sample populations, under a recessive model. We attempted to replicate this result in 10,265 Caucasian individuals, combining family-based, case-control, and general population studies, but found no support for a major role of this variant in obesity.
منابع مشابه
Common Genetic Variant of insig2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India
Background: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases. The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods: The variants were investig...
متن کاملComment on “A Common Genetic Variant Is Associated with Adult and Childhood Obesity”
Contrary to the findings of Herbert et al. (Reports, 14 April 2006, p. 279), homozygous carriers of the C allele of the rs7566605 variant near the INSIG2 gene did not exhibit a significantly increased risk for obesity in a large population-based cross-sectional German study. A subgroup analysis, however, revealed that this allele significantly increased the risk for obesity in already overweigh...
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2003;32:1–22. 4 Frayling TM, Timpson NJ, Weedon MN et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007;316:89–94. 5 Dina C, Meyre D, Gallina S et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007;39:724–26. 6 Brennan P, McKay J, Moore L et al. Uncommon CHEK2 mis-sense...
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Objective: The prevalence of obesity is rising in both developed and developing countries. Globally, it is estimated that nearly one billion adults are overweight at least 300 million of them are clinically obese. In Afghanistan no published data is available regarding non-communicable diseases including obesity. This paper reports the prevalence and associated risk factors of obesity among adu...
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Onset of obesity has been anticipated at earlier ages, and prevalence has dramatically increased worldwide over the past decades. Epidemic obesity is mainly attributable to modern lifestyle, but family studies prove the significant role of genes in the individual's predisposition to obesity. Advances in genotyping technologies have raised great hope and expectations that genetic testing will pa...
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عنوان ژورنال:
- Science
دوره 315 5809 شماره
صفحات -
تاریخ انتشار 2006